1,106 principal scientist jobs at 298 companies in United States
Principal Data Scientist
Seattle or United States
$206k-$269k/yr RemoteFull Time
Principal-level data scientist with expertise in quantitative analysis, experimentation, and data presentation; ability to develop hypotheses and influence product strategy; strong communication and storytelling skills.
Principal Data Scientist
San Francisco, California, United States
$206k-$269k/yr OnsiteFull Time
Principal-level data science role requiring deep technical expertise in ML, experimentation, and analytics; must lead end-to-end model development and mentor junior data scientists.
Principal Scientist, Biology
Foster City, California, United States
$196k-$253k/yr OnsiteFull Time
5+ YOEBS/virology/immunology/microbiology with 10+ years research experience, or MS with 8+ years, or PhD with 5+ years; expertise in virology; experience mentoring or supervising lab scientists.
Principal / Senior Principal Scientist- Investigative Toxicology
South San Francisco, California, United States
$142k-$322k/yr OnsiteFull Time
5+ YOEPh.D. in toxicology, neuroscience, pharmacology, or related field; 3-5+ years (Principal) or 5+ years (Senior Principal) industry experience; expertise in drug discovery, emerging modalities, advanced in vitro models, and statistical tools; relocation assistance available.
GraphPad Prism, Spotfire, JMP, R, Python
Principal Scientist, Target Binding
Somerville, Massachusetts, United States
$160k-$224k/yr OnsiteFull Time
8+ YOEPh.D. in biochemistry, biophysics, or related field with 8+ years industry experience; expertise in SPR, BLI, KinExA, and cell-binding assays; proven leadership in managing scientists and cross-functional programs.
SPR, BLI, KinExA
Principal Scientist / Associate Director, Developability & Protein Sciences
South San Francisco, California, United States
$175k-$190k/yr HybridFull Time
5+ YOEPhD in protein science, biochemistry, biophysics, or related field with 5+ years (Principal Scientist) or 8+ years (Associate Director) biopharma experience; hands-on bispecific/multispecific antibody expertise; developability methods; FPLC systems; cross-functional leadership; coding (Python/R).
DSF, DSC, analytical SEC, AC-SINS, DLS, IEX, cIEF, HIC, BVP ELISA, PSR, intact mass, CE-SDS, LC-MS, FPLC, AKTA, Python, R, Claude Code
Principal Clinical Scientist
Aliso Viejo, California, United States
$148k-$194k/yr OnsiteFull Time
5+ YOEMaster's degree in relevant science or medicine; 5+ years clinical research scientist experience; GCP knowledge; clinical protocol development; literature search expertise; strong writing and communication skills.
PubMed, MedLine
Principal Data Scientist
Austin, Texas, United States
HybridFull Time
5+ YOE3+ MgmtDoctorate-level data scientist with deep applied ML and statistical modeling experience in healthcare; expertise in model validation, reproducibility, governance, cloud platforms (Azure/Snowflake), Epic data, and team leadership.
Epic (EHR), VBA (TPA), Microsoft Azure, Snowflake, NIST AI Risk Management Framework (AI RMF), ISO/IEC 42001
Principal Scientist, Preclinical Pharmacology
Billerica, Massachusetts, United States
$127k-$215k/yr HybridFull Time
6+ YOEPhD (6+ years) or MSc (8+ years) in pharmacology, neuroscience, immunology, biology or related life science; substantial drug discovery experience; in vivo pharmacology leadership; experience with multiple therapeutic modalities; IND-enabling study design; managing scientists and CRO partnerships.
ELISA, MSD, IHC
Principal Scientist
Buffalo, New York, United States
$100k-$120k/yr OnsiteFull Time
5+ YOEMaster’s degree or equivalent in Dairy or Food Science and 5–10 years of related experience. Requires cheese processing, food technology, statistics, communication, and Microsoft Office skills.
Microsoft Word, Microsoft Excel, Microsoft PowerPoint
Principal Scientist
Branford, Connecticut, United States
OnsiteFull Time
5+ YOEPhD in immunology or related field with 5+ years postdoctoral/industry experience; expertise in human immunology, T cell immunobiology, immune-assay development, and translational research; strong communication and collaboration skills.
FACS, BD, Cytek
Principal Scientist
United States
RemoteFull Time
6+ YOEPh.D. in a relevant scientific area; 6+ years post-Ph.D. experience; excellent communication and English fluency.
Principal Scientist
Frisco, Texas, United States
$97k-$133k/yr OnsiteFull Time
7+ YOEM.S. required in chemistry, analytical chemistry, food science, biochemistry, chemical engineering, or related field; Ph.D. preferred. Requires 7+ years of analytical laboratory experience and expertise with analytical methods and instrumentation.
GC/TOF, HPLC, LC/MS, GCxGC, FTIR, ICP/MS, AI, automation
Principal Scientist
South San Francisco, California, United States
$203k-$236k/yr OnsiteFull Time
6+ YOEPh.D. in computational biology, human genetics, bioinformatics or related field with 6+ years post-doctoral or industry experience; expertise in genomic, transcriptomic, proteomic or single-cell analysis; proficiency in R and/or Python; strong interest in AI/ML and LLMs.
R, Python
Principal Scientist
Wood Dale, Illinois, United States
OnsiteFull Time
Advanced degree (PhD or MS) in Chemistry/Biochemistry, hands-on peptide synthesis and SPPS experience, ability to translate technical insight into commercial products, presentation and customer engagement experience, willingness to travel.
Principal Scientist
Cherry Hill, New Jersey, United States
$118k-$135k/yr OnsiteFull Time
10+ YOEBS in Chemistry (advanced degree preferred), 10+ years pharmaceutical/analytical lab experience, method development/validation leadership, expertise in HPLC/UPLC/GC/dissolution/UV/FTIR and cGMP/ALCOA+/FDA/ICH/USP/EP, strong technical writing and communication.
HPLC, UPLC, GC, Dissolution, UV, FTIR, cGMP, ALCOA+, FDA, ICH, USP, EP
Principal Scientist
Milford, Massachusetts, United States
$119k-$198k/yr OnsiteFull Time
5+ YOEPh.D. in Chemistry, Biochemistry, Chemical Engineering or related with 5+ years industrial experience, or M.S. with 7+ years; expertise in liquid chromatography, mass spectrometry, HPLC, and method development; strong leadership and communication skills.
HPLC, UHPLC, LC-MS, Mass Spectrometry
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